Assay Detail
Toxicity
CHEMBL5166206
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Cytotoxicity against hFOB 1.19 cells assessed as inhibition of cell growth incubated for 48 hrs by cell titer based MTS assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | hFOB 1.19 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 2-Amino-3-cyanothiophene Derivatives as Potent STAT3 Inhibitors for the Treatment of Osteosarcoma Growth and Metastasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.82 | 5.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178793 | — | — | 1 | 5.02 |
| CHEMBL5182175 | — | — | 1 | 4.90 |
| CHEMBL5175326 | — | — | 1 | 4.80 |
| CHEMBL5174100 | — | — | 1 | 4.71 |
| CHEMBL5204232 | — | — | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178793 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL5182175 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL5175326 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL5174100 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL5204232 | — | IC50 | = | 21300.0 | nM | 4.67 |