Assay Detail
Functional
CHEMBL5166209
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Antimigratory activity against human 143B cells assessed as reduction in cell migration measured after 12 hrs by wound healing assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 143B |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 2-Amino-3-cyanothiophene Derivatives as Potent STAT3 Inhibitors for the Treatment of Osteosarcoma Growth and Metastasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.06 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5174100 | — | — | 1 | 6.34 |
| CHEMBL5182175 | — | — | 1 | 6.32 |
| CHEMBL5175326 | — | — | 1 | 6.28 |
| CHEMBL5178793 | — | — | 1 | 5.99 |
| CHEMBL1829876 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5174100 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5182175 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5175326 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5178793 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL1829876 | — | IC50 | = | 4170.0 | nM | 5.38 |