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Assay Detail

CHEMBL5166394

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of full length mouse DAO transfected with CHO-K1 cells incubated for 30 mins by Amplex red and horseradish peroxidase based fluorescence assay
ChEMBL ↗
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Cell Type CHO-K1
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

D-amino-acid oxidase (CHEMBL2331068) ↗
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Discovery of a Novel Class of d-Amino Acid Oxidase Inhibitors Using the Schrödinger Computational Platform.
Tang H, Jensen K, Houang E, McRobb FM, Bhat S, Svensson M, Bochevarov A, Day T, Dahlgren MK, Bell JA, Frye L, Skene RJ, Lewis JH, Osborne JD, Tierney JP, Gordon JA, Palomero MA, Gallati C, Chapman RSL, Jones DR, Hirst KL, Sephton M, Chauhan A, Sharpe A, Tardia P, Dechaux EA, Taylor A, Waddell RD, Valentine A, Janssens HB, Aziz O, Bloomfield DE, Ladha S, Fraser IJ, Ellard JM.
J Med Chem (2022) 65 : 6775 -6802
PubMed 35482677 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 46 6.31 8.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3937708 — — 1 8.38
CHEMBL5188193 — — 1 7.00
CHEMBL5178413 — — 1 6.92
CHEMBL5179643 — — 1 6.66
CHEMBL5173262 — — 1 6.62
CHEMBL5189921 — — 1 6.60
CHEMBL5204161 — — 1 6.58
CHEMBL5179642 — — 1 6.54
CHEMBL5180296 — — 1 6.51
CHEMBL5176414 — — 1 6.47
CHEMBL5176256 — — 1 6.41
CHEMBL5196542 — — 1 6.37
CHEMBL5176574 — — 1 6.30
CHEMBL5178658 — — 1 6.29
CHEMBL5185870 — — 1 6.29
CHEMBL5202977 — — 1 6.27
CHEMBL5192292 — — 1 6.27
CHEMBL5190430 — — 1 6.25
CHEMBL5181983 — — 1 6.23
CHEMBL5188286 — — 1 6.23
CHEMBL5191702 — — 1 6.21
CHEMBL5208196 — — 1 6.17
CHEMBL5178002 — — 1 6.14
CHEMBL5186374 — — 1 6.11
CHEMBL5183719 — — 1 6.10
CHEMBL5184060 — — 1 6.01
CHEMBL5174518 — — 1 5.92
CHEMBL5201918 — — 1 5.85
CHEMBL5179598 — — 1 5.82
CHEMBL5190409 — — 1 5.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3937708 — EC50 = 4.2 nM 8.38
CHEMBL5188193 — EC50 = 100.0 nM 7.00
CHEMBL5178413 — EC50 = 120.0 nM 6.92
CHEMBL5179643 — EC50 = 220.0 nM 6.66
CHEMBL5173262 — EC50 = 240.0 nM 6.62
CHEMBL5189921 — EC50 = 250.0 nM 6.60
CHEMBL5204161 — EC50 = 260.0 nM 6.58
CHEMBL5179642 — EC50 = 290.0 nM 6.54
CHEMBL5180296 — EC50 = 310.0 nM 6.51
CHEMBL5176414 — EC50 = 340.0 nM 6.47
CHEMBL5176256 — EC50 = 390.0 nM 6.41
CHEMBL5196542 — EC50 = 430.0 nM 6.37
CHEMBL5176574 — EC50 = 500.0 nM 6.30
CHEMBL5178658 — EC50 = 510.0 nM 6.29
CHEMBL5185870 — EC50 = 510.0 nM 6.29
CHEMBL5202977 — EC50 = 540.0 nM 6.27
CHEMBL5192292 — EC50 = 540.0 nM 6.27
CHEMBL5190430 — EC50 = 560.0 nM 6.25
CHEMBL5181983 — EC50 = 590.0 nM 6.23
CHEMBL5188286 — EC50 = 590.0 nM 6.23
CHEMBL5191702 — EC50 = 620.0 nM 6.21
CHEMBL5208196 — EC50 = 680.0 nM 6.17
CHEMBL5178002 — EC50 = 720.0 nM 6.14
CHEMBL5186374 — EC50 = 780.0 nM 6.11
CHEMBL5183719 — EC50 = 790.0 nM 6.10
CHEMBL5184060 — EC50 = 970.0 nM 6.01
CHEMBL5174518 — EC50 = 1200.0 nM 5.92
CHEMBL5201918 — EC50 = 1400.0 nM 5.85
CHEMBL5179598 — EC50 = 1500.0 nM 5.82
CHEMBL5190409 — EC50 = 1500.0 nM 5.82
CHEMBL5178020 — EC50 = 1800.0 nM 5.75
CHEMBL5179752 — EC50 = 2300.0 nM 5.64
CHEMBL5186364 — EC50 = 4300.0 nM 5.37
CHEMBL5205206 — EC50 - — -
CHEMBL5191030 — EC50 - — -
CHEMBL5204414 — EC50 - — -
CHEMBL5184409 — EC50 - — -
CHEMBL5200372 — EC50 - — -
CHEMBL5203007 — EC50 - — -
CHEMBL5186214 — EC50 - — -
CHEMBL5174605 — EC50 - — -
CHEMBL5192952 — EC50 - — -
CHEMBL5176152 — EC50 - — -
CHEMBL5186984 — EC50 - — -
CHEMBL5202169 — EC50 - — -
CHEMBL5179137 — EC50 - — -