Assay Detail
Binding
CHEMBL5166790
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Inhibition of PHD2 (unknown origin) incubated for 15 mins by competitive fluorescence polarization assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor β Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.29 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2338329 | ROXADUSTAT | 4.0 | 1 | 7.33 |
| CHEMBL4163070 | — | — | 1 | 7.30 |
| CHEMBL5209093 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2338329 | ROXADUSTAT | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4163070 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5209093 | — | IC50 | = | 57.8 | nM | 7.24 |