Assay Detail
Binding
CHEMBL5166797
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Agonist activity at human TRbeta H435 mutant expressed in Escherichia coli BL21 (DE3) cells by alphascreen assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor β Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.58 | 5.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5200322 | — | — | 1 | 5.87 |
| CHEMBL5178993 | — | — | 1 | 5.62 |
| CHEMBL5181604 | — | — | 1 | 5.53 |
| CHEMBL5173831 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5200322 | — | EC50 | = | 1344.0 | nM | 5.87 |
| CHEMBL5178993 | — | EC50 | = | 2386.0 | nM | 5.62 |
| CHEMBL5181604 | — | EC50 | = | 2925.0 | nM | 5.53 |
| CHEMBL5173831 | — | EC50 | = | 5277.0 | nM | 5.28 |