Assay Detail
Binding
CHEMBL5167238
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Inhibition of Keap1-Nrf2 (unknown origin) protein-protein interaction by SPR assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein-Protein Interaction Inhibitors with an Alternative Binding Mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 6.76 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237245 | — | — | 1 | 7.70 |
| CHEMBL4174651 | — | — | 1 | 6.99 |
| CHEMBL3617852 | — | — | 1 | 6.96 |
| CHEMBL3632882 | — | — | 1 | 6.40 |
| CHEMBL2402207 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237245 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL4174651 | — | Kd | = | 102.0 | nM | 6.99 |
| CHEMBL3617852 | — | Kd | = | 110.0 | nM | 6.96 |
| CHEMBL3632882 | — | Kd | = | 400.0 | nM | 6.40 |
| CHEMBL2402207 | — | Kd | = | 1700.0 | nM | 5.77 |