Assay Detail
Binding
CHEMBL5167411
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Positive allosteric modulator activity at human MRGPRX1 expressed in HEK293 cells in presence of BAM8-22 by Fluo4-dye based FLIPR assay
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mas-related G-protein coupled receptor member X1 (CHEMBL5850) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and Biological Characterization of a Series of 2-Sulfonamidebenzamides as Allosteric Modulators of MrgX1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 61 | 6.48 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5195160 | — | — | 1 | 7.89 |
| CHEMBL5172913 | — | — | 1 | 7.85 |
| CHEMBL5205606 | — | — | 1 | 7.51 |
| CHEMBL5202767 | — | — | 1 | 7.27 |
| CHEMBL5185447 | — | — | 1 | 7.26 |
| CHEMBL5194692 | — | — | 1 | 7.16 |
| CHEMBL5177145 | — | — | 1 | 7.10 |
| CHEMBL5171656 | — | — | 1 | 7.01 |
| CHEMBL5200001 | — | — | 1 | 6.99 |
| CHEMBL5177388 | — | — | 1 | 6.91 |
| CHEMBL5208855 | — | — | 1 | 6.76 |
| CHEMBL5191110 | — | — | 1 | 6.69 |
| CHEMBL5205025 | — | — | 1 | 6.66 |
| CHEMBL5203677 | — | — | 1 | 6.54 |
| CHEMBL5179980 | — | — | 1 | 6.44 |
| CHEMBL5178316 | — | — | 1 | 6.43 |
| CHEMBL5173653 | — | — | 1 | 6.39 |
| CHEMBL5190176 | — | — | 1 | 6.36 |
| CHEMBL5188039 | — | — | 1 | 6.30 |
| CHEMBL5191409 | — | — | 1 | 6.30 |
| CHEMBL5205161 | — | — | 1 | 6.07 |
| CHEMBL5169615 | — | — | 1 | 6.04 |
| CHEMBL5192837 | — | — | 1 | 5.98 |
| CHEMBL5181857 | — | — | 1 | 5.96 |
| CHEMBL5176049 | — | — | 1 | 5.87 |
| CHEMBL5177134 | — | — | 1 | 5.85 |
| CHEMBL5193744 | — | — | 1 | 5.55 |
| CHEMBL5207586 | — | — | 1 | 5.50 |
| CHEMBL5193017 | — | — | 1 | 5.04 |
| CHEMBL5209542 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5195160 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5172913 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5205606 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5202767 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5185447 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5194692 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL5177145 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5171656 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL5200001 | — | EC50 | = | 103.0 | nM | 6.99 |
| CHEMBL5177388 | — | EC50 | = | 124.0 | nM | 6.91 |
| CHEMBL5208855 | — | EC50 | = | 173.0 | nM | 6.76 |
| CHEMBL5191110 | — | EC50 | = | 206.0 | nM | 6.69 |
| CHEMBL5205025 | — | EC50 | = | 217.0 | nM | 6.66 |
| CHEMBL5203677 | — | EC50 | = | 285.0 | nM | 6.54 |
| CHEMBL5179980 | — | EC50 | = | 366.0 | nM | 6.44 |
| CHEMBL5178316 | — | EC50 | = | 369.0 | nM | 6.43 |
| CHEMBL5173653 | — | EC50 | = | 407.0 | nM | 6.39 |
| CHEMBL5190176 | — | EC50 | = | 435.0 | nM | 6.36 |
| CHEMBL5188039 | — | EC50 | = | 502.0 | nM | 6.30 |
| CHEMBL5191409 | — | EC50 | = | 506.0 | nM | 6.30 |
| CHEMBL5205161 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5169615 | — | EC50 | = | 915.0 | nM | 6.04 |
| CHEMBL5192837 | — | EC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL5181857 | — | EC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL5176049 | — | EC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL5177134 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5193744 | — | EC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL5207586 | — | EC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL5193017 | — | EC50 | = | 9010.0 | nM | 5.04 |
| CHEMBL5209542 | — | EC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL5209190 | — | EC50 | - | — | - | |
| CHEMBL5190795 | — | EC50 | - | — | - | |
| CHEMBL5197841 | — | EC50 | - | — | - | |
| CHEMBL5184689 | — | EC50 | - | — | - | |
| CHEMBL5181514 | — | EC50 | - | — | - | |
| CHEMBL5209208 | — | EC50 | - | — | - | |
| CHEMBL5172305 | — | EC50 | - | — | - | |
| CHEMBL5176103 | — | EC50 | - | — | - | |
| CHEMBL5171590 | — | EC50 | - | — | - | |
| CHEMBL5189843 | — | EC50 | - | — | - | |
| CHEMBL5173037 | — | EC50 | - | — | - | |
| CHEMBL5189972 | — | EC50 | - | — | - | |
| CHEMBL5199642 | — | EC50 | - | — | - | |
| CHEMBL5206207 | — | EC50 | - | — | - | |
| CHEMBL5186474 | — | EC50 | - | — | - | |
| CHEMBL5207415 | — | EC50 | - | — | - | |
| CHEMBL5202757 | — | EC50 | - | — | - | |
| CHEMBL5172368 | — | EC50 | - | — | - | |
| CHEMBL5207364 | — | EC50 | - | — | - | |
| CHEMBL5205222 | — | EC50 | - | — | - |