Assay Detail
Binding
CHEMBL5167427
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length beta-catenin (1 to 781 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)-N-terminal biotinylated human BCL9 (350 to 375 residues) protein-protein interaction incubated for 1 hr by Alphascreen assay
44
Total Activities
22
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
beta-catenin-B-cell lymphoma 9 protein complex (CHEMBL3885525) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
New ZW4864 Derivatives as Small-Molecule Inhibitors for the β-Catenin/BCL9 Protein-Protein Interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.03 | 6.06 |
| Ki | 22 | 5.09 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4846565 | — | — | 2 | 6.12 |
| CHEMBL5190873 | — | — | 2 | 6.07 |
| CHEMBL5208427 | — | — | 2 | 5.92 |
| CHEMBL5187855 | — | — | 2 | 5.75 |
| CHEMBL5176904 | — | — | 2 | 5.70 |
| CHEMBL4863751 | — | — | 2 | 5.68 |
| CHEMBL5173336 | — | — | 2 | 5.57 |
| CHEMBL5192048 | — | — | 2 | 5.17 |
| CHEMBL5190706 | — | — | 2 | 5.17 |
| CHEMBL5181790 | — | — | 2 | 5.10 |
| CHEMBL5181564 | — | — | 2 | 5.01 |
| CHEMBL5209451 | — | — | 2 | 4.96 |
| CHEMBL5203221 | — | — | 2 | 4.82 |
| CHEMBL5175072 | — | — | 2 | 4.82 |
| CHEMBL5200836 | — | — | 2 | 4.80 |
| CHEMBL5181837 | — | — | 2 | 4.68 |
| CHEMBL5192661 | — | — | 2 | 4.62 |
| CHEMBL5205267 | — | — | 2 | 4.60 |
| CHEMBL5181873 | — | — | 2 | 4.51 |
| CHEMBL5202892 | — | — | 2 | 4.43 |
| CHEMBL5209340 | — | — | 2 | 4.41 |
| CHEMBL5169603 | — | — | 2 | 4.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4846565 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL5190873 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL4846565 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL5190873 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL5208427 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL5208427 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5187855 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL5176904 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL4863751 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL5187855 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4863751 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5176904 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5173336 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL5173336 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5192048 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL5190706 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL5192048 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL5181790 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL5190706 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL5181790 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL5181564 | — | Ki | = | 9800.0 | nM | 5.01 |
| CHEMBL5209451 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL5209451 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5181564 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5175072 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL5203221 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL5200836 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL5203221 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5175072 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5200836 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5181837 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL5181837 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL5192661 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL5205267 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL5205267 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL5192661 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL5181873 | — | Ki | = | 31000.0 | nM | 4.51 |
| CHEMBL5202892 | — | Ki | = | 37000.0 | nM | 4.43 |
| CHEMBL5181873 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL5209340 | — | Ki | = | 39000.0 | nM | 4.41 |
| CHEMBL5209340 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL5202892 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL5169603 | — | Ki | = | 73000.0 | nM | 4.14 |
| CHEMBL5169603 | — | IC50 | = | 81000.0 | nM | 4.09 |