Assay Detail
Functional
CHEMBL5167434
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Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth measured by MTS method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF-10A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New ZW4864 Derivatives as Small-Molecule Inhibitors for the β-Catenin/BCL9 Protein-Protein Interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.41 | 4.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5190873 | — | — | 1 | 4.62 |
| CHEMBL5187855 | — | — | 1 | 4.54 |
| CHEMBL5173336 | — | — | 1 | 4.44 |
| CHEMBL4846565 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5190873 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL5187855 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL5173336 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4846565 | — | IC50 | = | 92000.0 | nM | 4.04 |