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Assay Detail

CHEMBL5167580

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human CK2alpha2 using RRRDDDSDDD peptide as substrate in presence of [gamma-33P]ATP by radiometric based scintillation proximity assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5-<i>a</i>]pyrimidine-Based Macrocycles.
Kurz CG, Preuss F, Tjaden A, Cusack M, Amrhein JA, Chatterjee D, Mathea S, Berger LM, Berger BT, Krämer A, Weller M, Weiss T, Müller S, Knapp S, Hanke T.
J Med Chem (2022) 65 : 7799 -7817
PubMed 35608370 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.42 6.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5087558 1 6.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5087558 IC50 = 380.0 nM 6.42