Assay Detail
Functional
CHEMBL5167607
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human LN-18 cells assessed as reduction in cell viability after 1 to 7 days by resazurin dye based fluorimetric analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LN-18 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5-<i>a</i>]pyrimidine-Based Macrocycles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.33 | 5.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5191892 | — | — | 1 | 5.71 |
| CHEMBL5087558 | — | — | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5191892 | — | EC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL5087558 | — | EC50 | = | 11230.0 | nM | 4.95 |