Assay Detail
Binding
CHEMBL5167638
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kdelta in IgM stimulated human Raji cells incubated for 10 mins by AlphaLISA assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Raji |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and Optimization of Thienopyrimidine Derivatives as Potent and Selective PI3Kδ Inhibitors for the Treatment of B-Cell Malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.16 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5192588 | — | — | 1 | 7.47 |
| CHEMBL3643413 | LENIOLISIB | 4.0 | 1 | 7.20 |
| CHEMBL5203775 | — | — | 1 | 7.12 |
| CHEMBL5204818 | — | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5192588 | — | IC50 | = | 33.7 | nM | 7.47 |
| CHEMBL3643413 | LENIOLISIB | IC50 | = | 62.8 | nM | 7.20 |
| CHEMBL5203775 | — | IC50 | = | 75.7 | nM | 7.12 |
| CHEMBL5204818 | — | IC50 | = | 137.1 | nM | 6.86 |