Assay Detail
Functional
CHEMBL5167698
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Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by CCK-8 assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Novel Series of Imipridone Compounds as <i>Homo sapiens</i> Caseinolytic Protease P Agonists with Potent Antitumor Activities In Vitro and In Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.98 | 4.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5196543 | — | — | 1 | 4.98 |
| CHEMBL4297310 | DORDAVIPRONE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5196543 | — | IC50 | = | 10470.0 | nM | 4.98 |
| CHEMBL4297310 | DORDAVIPRONE | IC50 | > | 20000.0 | nM | - |