Assay Detail
Functional
CHEMBL5167705
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Antiproliferative activity against human SW-620 cells incubated for 48 hrs by CCK-8 assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Novel Series of Imipridone Compounds as <i>Homo sapiens</i> Caseinolytic Protease P Agonists with Potent Antitumor Activities In Vitro and In Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.54 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5191392 | — | — | 1 | 7.22 |
| CHEMBL5205960 | — | — | 1 | 7.05 |
| CHEMBL5172282 | — | — | 1 | 6.82 |
| CHEMBL5170508 | — | — | 1 | 6.77 |
| CHEMBL5180553 | — | — | 1 | 6.72 |
| CHEMBL5196543 | — | — | 1 | 6.19 |
| CHEMBL4297310 | DORDAVIPRONE | 3.0 | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5191392 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5205960 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5172282 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5170508 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5180553 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5196543 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4297310 | DORDAVIPRONE | IC50 | = | 9170.0 | nM | 5.04 |