Assay Detail
Toxicity
CHEMBL5168166
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hERG channel assessed as prolongation of QT interval by patch clamp method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 1,6-Naphthyridin-2(1<i>H</i>)-one Derivatives as Novel, Potent, and Selective FGFR4 Inhibitors for the Treatment of Hepatocellular Carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.77 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74656 | REL-CISAPRIDE | — | 1 | 6.77 |
| CHEMBL5200584 | — | — | 1 | - |
| CHEMBL4514636 | FISOGATINIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74656 | REL-CISAPRIDE | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5200584 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4514636 | FISOGATINIB | IC50 | > | 30000.0 | nM | - |