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Assay Detail

CHEMBL5168258

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Functional
Antiproliferative activity against human HCCLM9 cells treated for 72 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCCLM9
Confidence 1 — Organism
Curated By Autocuration

Target

HCCLM9 (CHEMBL5209889)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, Synthesis, and Biological Evaluation of Novel Evodiamine Derivatives as Potential Antihepatocellular Carcinoma Agents.
Lei F, Xiong Y, Wang Y, Zhang H, Liang Z, Li J, Feng Y, Hao X, Wang Z.
J Med Chem (2022) 65 : 7975 -7992
PubMed 35639640 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 5.61 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5187355 1 7.00
CHEMBL5203347 1 6.96
CHEMBL5175429 1 6.85
CHEMBL5172424 1 6.55
CHEMBL5206621 1 6.51
CHEMBL5191804 1 6.05
CHEMBL5206564 1 5.57
CHEMBL1336 SORAFENIB 4.0 1 5.50
CHEMBL5191422 1 5.42
CHEMBL5205400 1 5.38
CHEMBL5172309 1 5.22
CHEMBL5199479 1 5.20
CHEMBL5205243 1 5.18
CHEMBL5198904 1 5.16
CHEMBL5183875 1 5.15
CHEMBL5181828 1 5.11
CHEMBL81925 1 5.03
CHEMBL5200900 1 4.97
CHEMBL5198531 1 4.92
CHEMBL5175435 1 4.41
CHEMBL5190805 1 -
CHEMBL5192391 1 -
CHEMBL5205528 1 -
CHEMBL5171093 1 -
CHEMBL5178647 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5187355 IC50 = 100.0 nM 7.00
CHEMBL5203347 IC50 = 110.0 nM 6.96
CHEMBL5175429 IC50 = 140.0 nM 6.85
CHEMBL5172424 IC50 = 280.0 nM 6.55
CHEMBL5206621 IC50 = 310.0 nM 6.51
CHEMBL5191804 IC50 = 890.0 nM 6.05
CHEMBL5206564 IC50 = 2670.0 nM 5.57
CHEMBL1336 SORAFENIB IC50 = 3150.0 nM 5.50
CHEMBL5191422 IC50 = 3780.0 nM 5.42
CHEMBL5205400 IC50 = 4210.0 nM 5.38
CHEMBL5172309 IC50 = 6040.0 nM 5.22
CHEMBL5199479 IC50 = 6340.0 nM 5.20
CHEMBL5205243 IC50 = 6620.0 nM 5.18
CHEMBL5198904 IC50 = 6900.0 nM 5.16
CHEMBL5183875 IC50 = 7050.0 nM 5.15
CHEMBL5181828 IC50 = 7750.0 nM 5.11
CHEMBL81925 IC50 = 9270.0 nM 5.03
CHEMBL5200900 IC50 = 10810.0 nM 4.97
CHEMBL5198531 IC50 = 11980.0 nM 4.92
CHEMBL5175435 IC50 = 39000.0 nM 4.41
CHEMBL5190805 IC50 > 18000.0 nM -
CHEMBL5192391 IC50 > 18000.0 nM -
CHEMBL5205528 IC50 > 18000.0 nM -
CHEMBL5171093 IC50 > 18000.0 nM -
CHEMBL5178647 IC50 > 18000.0 nM -