Assay Detail
Functional
CHEMBL5168378
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SMMC-7721 cells treated for 72 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SMMC-7721 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Novel Evodiamine Derivatives as Potential Antihepatocellular Carcinoma Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.67 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5187355 | — | — | 1 | 7.10 |
| CHEMBL5203347 | — | — | 1 | 7.05 |
| CHEMBL5172424 | — | — | 1 | 6.57 |
| CHEMBL5175435 | — | — | 1 | 6.46 |
| CHEMBL5206621 | — | — | 1 | 6.31 |
| CHEMBL5175429 | — | — | 1 | 6.11 |
| CHEMBL5191804 | — | — | 1 | 6.04 |
| CHEMBL5206564 | — | — | 1 | 5.83 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.62 |
| CHEMBL5199479 | — | — | 1 | 5.53 |
| CHEMBL81925 | — | — | 1 | 5.52 |
| CHEMBL5191422 | — | — | 1 | 5.40 |
| CHEMBL5205400 | — | — | 1 | 5.40 |
| CHEMBL5172309 | — | — | 1 | 5.36 |
| CHEMBL5183875 | — | — | 1 | 5.29 |
| CHEMBL5181828 | — | — | 1 | 5.24 |
| CHEMBL5205243 | — | — | 1 | 5.23 |
| CHEMBL5198904 | — | — | 1 | 5.16 |
| CHEMBL5200900 | — | — | 1 | 5.15 |
| CHEMBL5198531 | — | — | 1 | 5.09 |
| CHEMBL5192391 | — | — | 1 | 5.04 |
| CHEMBL5171093 | — | — | 1 | 4.96 |
| CHEMBL5205528 | — | — | 1 | 4.89 |
| CHEMBL5190805 | — | — | 1 | - |
| CHEMBL5178647 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5187355 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5203347 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5172424 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5175435 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5206621 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5175429 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5191804 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL5206564 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL5199479 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL81925 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL5191422 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL5205400 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL5172309 | — | IC50 | = | 4380.0 | nM | 5.36 |
| CHEMBL5183875 | — | IC50 | = | 5110.0 | nM | 5.29 |
| CHEMBL5181828 | — | IC50 | = | 5770.0 | nM | 5.24 |
| CHEMBL5205243 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL5198904 | — | IC50 | = | 6920.0 | nM | 5.16 |
| CHEMBL5200900 | — | IC50 | = | 7140.0 | nM | 5.15 |
| CHEMBL5198531 | — | IC50 | = | 8150.0 | nM | 5.09 |
| CHEMBL5192391 | — | IC50 | = | 9180.0 | nM | 5.04 |
| CHEMBL5171093 | — | IC50 | = | 10910.0 | nM | 4.96 |
| CHEMBL5205528 | — | IC50 | = | 13010.0 | nM | 4.89 |
| CHEMBL5190805 | — | IC50 | > | 18000.0 | nM | - |
| CHEMBL5178647 | — | IC50 | > | 18000.0 | nM | - |