Assay Detail
Functional
CHEMBL5168438
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by cell titer glo luminescent assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Small Molecules Simultaneously Targeting NAD(P)H:Quinone Oxidoreductase 1 and Nicotinamide Phosphoribosyltransferase: Treatment of Drug-Resistant Non-small-Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.42 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 7.55 |
| CHEMBL5202802 | — | — | 1 | 5.94 |
| CHEMBL5180052 | — | — | 1 | 5.82 |
| CHEMBL5202825 | — | — | 1 | 5.69 |
| CHEMBL5177187 | — | — | 1 | 5.63 |
| CHEMBL5173172 | — | — | 1 | 5.63 |
| CHEMBL5183089 | — | — | 1 | 5.60 |
| CHEMBL5174585 | — | — | 1 | 5.55 |
| CHEMBL5192703 | — | — | 1 | 5.55 |
| CHEMBL5179366 | — | — | 1 | 5.54 |
| CHEMBL5188880 | — | — | 1 | 5.54 |
| CHEMBL5201382 | — | — | 1 | 5.49 |
| CHEMBL5195102 | — | — | 1 | 5.49 |
| CHEMBL5197473 | — | — | 1 | 5.48 |
| CHEMBL5191219 | — | — | 1 | 5.37 |
| CHEMBL5175816 | — | — | 1 | 5.36 |
| CHEMBL5177828 | — | — | 1 | 5.36 |
| CHEMBL5184926 | — | — | 1 | 5.35 |
| CHEMBL5190901 | — | — | 1 | 5.34 |
| CHEMBL5179145 | — | — | 1 | 5.30 |
| CHEMBL5179968 | — | — | 1 | 5.29 |
| CHEMBL5208752 | — | — | 1 | 5.20 |
| CHEMBL5170476 | — | — | 1 | 5.20 |
| CHEMBL187266 | TANSHINONE IIA | — | 1 | 5.17 |
| CHEMBL5177650 | — | — | 1 | 5.09 |
| CHEMBL5194620 | — | — | 1 | 5.09 |
| CHEMBL5189055 | — | — | 1 | 5.03 |
| CHEMBL5199947 | — | — | 1 | 5.02 |
| CHEMBL5203137 | — | — | 1 | 4.79 |
| CHEMBL5175845 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5202802 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL5180052 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5202825 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL5177187 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL5173172 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL5183089 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5174585 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL5192703 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL5179366 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5188880 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL5201382 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL5195102 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL5197473 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL5191219 | — | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL5177828 | — | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL5175816 | — | IC50 | = | 4370.0 | nM | 5.36 |
| CHEMBL5184926 | — | IC50 | = | 4430.0 | nM | 5.35 |
| CHEMBL5190901 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5179145 | — | IC50 | = | 4970.0 | nM | 5.30 |
| CHEMBL5179968 | — | IC50 | = | 5070.0 | nM | 5.29 |
| CHEMBL5208752 | — | IC50 | = | 6330.0 | nM | 5.20 |
| CHEMBL5170476 | — | IC50 | = | 6270.0 | nM | 5.20 |
| CHEMBL187266 | TANSHINONE IIA | IC50 | = | 6680.0 | nM | 5.17 |
| CHEMBL5177650 | — | IC50 | = | 8030.0 | nM | 5.09 |
| CHEMBL5194620 | — | IC50 | = | 8210.0 | nM | 5.09 |
| CHEMBL5189055 | — | IC50 | = | 9340.0 | nM | 5.03 |
| CHEMBL5199947 | — | IC50 | = | 9470.0 | nM | 5.02 |
| CHEMBL5203137 | — | IC50 | = | 16220.0 | nM | 4.79 |
| CHEMBL5175845 | — | IC50 | = | 17390.0 | nM | 4.76 |
| CHEMBL5170617 | — | IC50 | = | 21640.0 | nM | 4.67 |
| CHEMBL5174537 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5195477 | — | IC50 | > | 50000.0 | nM | - |