Assay Detail
Binding
CHEMBL5168439
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human NAMPT incubated for 60 mins by colorimetric assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nicotinamide phosphoribosyltransferase (CHEMBL1744525) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Small Molecules Simultaneously Targeting NAD(P)H:Quinone Oxidoreductase 1 and Nicotinamide Phosphoribosyltransferase: Treatment of Drug-Resistant Non-small-Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.76 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 7.46 |
| CHEMBL5202802 | — | — | 1 | 6.74 |
| CHEMBL5195102 | — | — | 1 | 6.38 |
| CHEMBL5180052 | — | — | 1 | 6.28 |
| CHEMBL5177187 | — | — | 1 | 6.03 |
| CHEMBL5183089 | — | — | 1 | 6.02 |
| CHEMBL5184926 | — | — | 1 | 5.68 |
| CHEMBL5201382 | — | — | 1 | 5.61 |
| CHEMBL5179366 | — | — | 1 | 5.52 |
| CHEMBL5173172 | — | — | 1 | 5.45 |
| CHEMBL5197473 | — | — | 1 | 5.42 |
| CHEMBL5190901 | — | — | 1 | 5.20 |
| CHEMBL5177828 | — | — | 1 | 4.93 |
| CHEMBL5199947 | — | — | 1 | 4.88 |
| CHEMBL5208752 | — | — | 1 | 4.78 |
| CHEMBL187266 | TANSHINONE IIA | — | 1 | - |
| CHEMBL5194620 | — | — | 1 | - |
| CHEMBL5189055 | — | — | 1 | - |
| CHEMBL5188880 | — | — | 1 | - |
| CHEMBL5175816 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5202802 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL5195102 | — | IC50 | = | 421.0 | nM | 6.38 |
| CHEMBL5180052 | — | IC50 | = | 526.0 | nM | 6.28 |
| CHEMBL5177187 | — | IC50 | = | 941.0 | nM | 6.03 |
| CHEMBL5183089 | — | IC50 | = | 964.0 | nM | 6.02 |
| CHEMBL5184926 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL5201382 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL5179366 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL5173172 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL5197473 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL5190901 | — | IC50 | = | 6320.0 | nM | 5.20 |
| CHEMBL5177828 | — | IC50 | = | 11650.0 | nM | 4.93 |
| CHEMBL5199947 | — | IC50 | = | 13210.0 | nM | 4.88 |
| CHEMBL5208752 | — | IC50 | = | 16720.0 | nM | 4.78 |
| CHEMBL187266 | TANSHINONE IIA | IC50 | - | — | - | |
| CHEMBL5194620 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5189055 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5188880 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5175816 | — | IC50 | > | 20000.0 | nM | - |