Assay Detail
Functional
CHEMBL5168442
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Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth measured after 72 hrs by cell titer glo luminescent assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549/TR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Small Molecules Simultaneously Targeting NAD(P)H:Quinone Oxidoreductase 1 and Nicotinamide Phosphoribosyltransferase: Treatment of Drug-Resistant Non-small-Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.93 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5202802 | — | — | 1 | 5.39 |
| CHEMBL5180052 | — | — | 1 | 5.17 |
| CHEMBL5177187 | — | — | 1 | 5.14 |
| CHEMBL5183089 | — | — | 1 | 5.08 |
| CHEMBL5195102 | — | — | 1 | 5.00 |
| CHEMBL5179366 | — | — | 1 | 4.90 |
| CHEMBL5201382 | — | — | 1 | 4.80 |
| CHEMBL5197473 | — | — | 1 | 4.77 |
| CHEMBL5184926 | — | — | 1 | 4.59 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5202802 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5180052 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL5177187 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL5183089 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL5195102 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL5179366 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL5201382 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL5197473 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL5184926 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 34300.0 | nM | 4.46 |