Assay Detail
Functional
CHEMBL5168495
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Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as cAMP accumulation incubated for 30 mins in absence of BETP by plate reader method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.95 | 10.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414357 | EXENATIDE | 4.0 | 1 | 10.21 |
| CHEMBL4084119 | LIRAGLUTIDE | 4.0 | 1 | 9.41 |
| CHEMBL5191519 | — | — | 1 | 9.12 |
| CHEMBL4518483 | DANUGLIPRON | 2.0 | 1 | 8.96 |
| CHEMBL5182388 | — | — | 1 | 7.02 |
| CHEMBL5209130 | — | — | 1 | 5.58 |
| CHEMBL5208289 | — | — | 1 | 5.34 |
| CHEMBL5206786 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414357 | EXENATIDE | EC50 | = | 0.061 | nM | 10.21 |
| CHEMBL4084119 | LIRAGLUTIDE | EC50 | = | 0.39 | nM | 9.41 |
| CHEMBL5191519 | — | EC50 | = | 0.75 | nM | 9.12 |
| CHEMBL4518483 | DANUGLIPRON | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5182388 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL5209130 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5208289 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5206786 | — | EC50 | > | 20000.0 | nM | - |