Assay Detail
Functional
CHEMBL5168501
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Agonist activity at human GLP-1R expressed in PathHunter CHO-K1 GLP1R beta-arrestin-2 cell assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins in presence of BETP by PathHunter assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.46 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5208289 | — | — | 1 | 5.82 |
| CHEMBL5182388 | — | — | 1 | 5.55 |
| CHEMBL5209130 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5208289 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5182388 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5209130 | — | EC50 | = | 9600.0 | nM | 5.02 |