Assay Detail
Functional
CHEMBL5168503
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Agonist activity at human GLP-1R expressed in PathHunter CHO-K1 GLP1R beta-arrestin-2 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins in absence of BETP by PathHunter assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.77 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4084119 | LIRAGLUTIDE | 4.0 | 1 | 7.77 |
| CHEMBL5209130 | — | — | 1 | - |
| CHEMBL5208289 | — | — | 1 | - |
| CHEMBL5182388 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4084119 | LIRAGLUTIDE | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5209130 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL5208289 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL5182388 | — | EC50 | > | 30000.0 | nM | - |