Assay Detail
Functional
CHEMBL5168510
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Agonist activity at human GLP-1R expressed in PathHunter CHO-K1 GLP1R beta-arrestin-1 cell assessed as induction of beta-arrestin 1 recruitment incubated for 90 mins by pathHunter assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PathHunter CHO-K1 GLP1R beta-arrestin-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.01 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414357 | EXENATIDE | 4.0 | 1 | 7.85 |
| CHEMBL4084119 | LIRAGLUTIDE | 4.0 | 1 | 7.47 |
| CHEMBL5191519 | — | — | 1 | 6.60 |
| CHEMBL4518483 | DANUGLIPRON | 2.0 | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414357 | EXENATIDE | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4084119 | LIRAGLUTIDE | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5191519 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4518483 | DANUGLIPRON | EC50 | = | 760.0 | nM | 6.12 |