Assay Detail
Binding
CHEMBL5168516
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]PF-06883365 from FAP-tagged human GLP-1R expressed in CHO cells assessed as inhibition constant by radioligand binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.22 | 10.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414357 | EXENATIDE | 4.0 | 1 | 10.28 |
| CHEMBL4084119 | LIRAGLUTIDE | 4.0 | 1 | 8.20 |
| CHEMBL5191519 | — | — | 1 | 7.29 |
| CHEMBL4518483 | DANUGLIPRON | 2.0 | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414357 | EXENATIDE | Ki | = | 0.053 | nM | 10.28 |
| CHEMBL4084119 | LIRAGLUTIDE | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL5191519 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL4518483 | DANUGLIPRON | Ki | = | 80.0 | nM | 7.10 |