Assay Detail

CHEMBL5168517

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Activation of cynomolgus monkey GLP-1R expressed in CHO cells assessed as increase in cAMP accumulation

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Macaca fascicularis
Cell Type	CHO
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.

Griffith DA, Edmonds DJ, Fortin JP, Kalgutkar AS, Kuzmiski JB, Loria PM, Saxena AR, Bagley SW, Buckeridge C, Curto JM, Derksen DR, Dias JM, Griffor MC, Han S, Jackson VM, Landis MS, Lettiere D, Limberakis C, Liu Y, Mathiowetz AM, Patel JC, Piotrowski DW, Price DA, Ruggeri RB, Tess DA.
J Med Chem (2022) 65 : 8208 -8226
PubMed 35647711 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	8.36	8.36

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4518483	DANUGLIPRON	2.0	1	8.36

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4518483	DANUGLIPRON	EC50	=	4.4	nM	8.36