Assay Detail
Binding
CHEMBL5168563
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Degradation of BCL6 in human OCI-Ly1 cells incubated for 2 hrs by MSD assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | OCI-Ly1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 <i>In Vivo</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 7.87 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5205388 | — | — | 1 | 9.15 |
| CHEMBL5205212 | — | — | 1 | 8.66 |
| CHEMBL5204505 | — | — | 1 | 8.57 |
| CHEMBL5172641 | — | — | 1 | 8.20 |
| CHEMBL5208698 | — | — | 1 | 8.15 |
| CHEMBL5193571 | — | — | 1 | 8.01 |
| CHEMBL5172688 | — | — | 1 | 7.49 |
| CHEMBL5200057 | — | — | 1 | 7.46 |
| CHEMBL4445645 | — | — | 1 | 7.27 |
| CHEMBL4559074 | — | — | 1 | 7.10 |
| CHEMBL5187061 | — | — | 1 | 6.56 |
| CHEMBL5203177 | — | — | 1 | - |
| CHEMBL5174171 | — | — | 1 | - |
| CHEMBL5194697 | — | — | 1 | - |
| CHEMBL5205838 | — | — | 1 | - |
| CHEMBL5196650 | — | — | 1 | - |
| CHEMBL5180823 | — | — | 1 | - |
| CHEMBL5171631 | — | — | 1 | - |
| CHEMBL5181921 | — | — | 1 | - |
| CHEMBL5171519 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5205388 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5205212 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL5204505 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL5172641 | — | EC50 | = | 6.3 | nM | 8.20 |
| CHEMBL5208698 | — | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL5193571 | — | EC50 | = | 9.8 | nM | 8.01 |
| CHEMBL5172688 | — | EC50 | = | 32.6 | nM | 7.49 |
| CHEMBL5200057 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4445645 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4559074 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5187061 | — | EC50 | = | 276.0 | nM | 6.56 |
| CHEMBL5203177 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL5174171 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL5194697 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL5205838 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL5196650 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL5180823 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL5171631 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL5181921 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL5171519 | — | EC50 | > | 2000.0 | nM | - |