Assay Detail
Functional
CHEMBL5209601
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Substrate uptake and inhibition of the chromaffin granule amine transporter (VAT1, VMAT1, SLC18A1) as assessed by uptake of a fluorescent substrate (FFN206) in HEK-293 JumpIN-SLC18A1 cells (PubChem AID: 1794818)
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Chromaffin granule amine transporter (CHEMBL1838) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
FFN206 based assay for SLC18A1 using HEK-293 SLC18A1 OE cells
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.30 | 7.30 |
| EC50 | 1 | 5.70 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL772 | RESERPINE | 4.0 | 1 | 7.30 |
| CHEMBL5209629 | — | — | 1 | 5.70 |
| CHEMBL117785 | TETRABENAZINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL772 | RESERPINE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5209629 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL117785 | TETRABENAZINE | IC50 | > | 10000.0 | nM | - |