Assay Detail
Functional
CHEMBL5209602
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Substrate uptake and inhibition of the Vesicular Amine Transporter 2 (VMAT2, SLC18A2) as assessed by uptake of a fluorescent substrate (FFN206) in HEK-293 JumpIN-SLC18A2 cells (PubChem AID: 1794817)
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Synaptic vesicular amine transporter (CHEMBL1893) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
FFN206 based assay for SLC18A2 using HEK-293 SLC18A2 OE cells
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.76 | 7.81 |
| EC50 | 1 | 5.45 | 5.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL772 | RESERPINE | 4.0 | 1 | 7.81 |
| CHEMBL117785 | TETRABENAZINE | 4.0 | 1 | 7.70 |
| CHEMBL5209629 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL772 | RESERPINE | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL117785 | TETRABENAZINE | IC50 | = | 19.8 | nM | 7.70 |
| CHEMBL5209629 | — | EC50 | = | 3560.0 | nM | 5.45 |