Assay Detail
Functional
CHEMBL5209961
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity Phenotypic Cellular interaction (CellTiter-Glo assay (Promega; cell proliferation in HCC70 cells)) EUB0000130bCl AKT2
1
Total Activities
1
Compounds Tested
1
Activity Types
3
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Category | Affinity phenotypic cellular assay |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomics Library wave 3
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.52 | 6.52 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Mode of action | Mode of action | - | — | Allosteric inhibitor |
| Protein family | Protein family | - | — | Protein Kinase |
| Recommended concentration | Recommended concentration | 1.0 | uM | — |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4635254 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4635254 | — | IC50 | = | 300.0 | nM | 6.52 |