Assay Detail
Binding
CHEMBL5210280
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity On-target Cellular interaction (Clamp electrophysiology (Ephys) assay (inhibition of voltage-induced current in HEK-293 cells expressing human TRPM8 channel)) EUB0000304b TRPM8
1
Total Activities
1
Compounds Tested
1
Activity Types
4
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Category | Affinity on-target cellular assay |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily M member 8 (CHEMBL1075319) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Affinity On-target Cellular Literature for EUbOPEN Chemogenomics Library wave 3
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.99 | 6.99 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Mode of action | Mode of action | - | — | Antagonist |
| Negative control | Negative control | - | — | PF-05257137 |
| Protein family | Protein family | - | — | TRP channel |
| Recommended concentration | Recommended concentration | 1.0 | uM | — |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3577885 | PF-05105679 | 1.0 | 1 | 6.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3577885 | PF-05105679 | IC50 | = | 103.0 | nM | 6.99 |