Assay Detail
Binding
CHEMBL5215149
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PROTAC activity at VHL/KRAS G12C mutant in human NCI- H2030 cells assessed as induction of KRAS G12C degradation by western blot analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NCI-H2030 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
von Hippel-Lindau disease tumor suppressor/KRAS (CHEMBL5169273) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
PROTACs to address the challenges facing small molecule inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 6.60 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4594350 | ADAGRASIB | 4.0 | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4594350 | ADAGRASIB | EC50 | = | 250.0 | nM | 6.60 |