Assay Detail
Binding
CHEMBL5215248
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged FLT-3 (unknown origin) (Tyr567-Ser993 residues) expressed in baculovirus infected Sf9 insect cells using GGMEDIYFEFMGGKKK as peptide substrate incubated for 4 hrs in presence of ATP by Kinase-Glo assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Therapeutic progression of quinazolines as targeted chemotherapeutic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.72 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4864729 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4864729 | — | IC50 | = | 19.0 | nM | 7.72 |