Assay Detail
Binding
CHEMBL5215368
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Inhibition of PP1 (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Antitumor potential of the protein phosphatase inhibitor, cantharidin, and selected derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.66 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48449 | CANTHARIDIN | 4.0 | 1 | 6.33 |
| CHEMBL1234720 | — | — | 1 | 6.25 |
| CHEMBL5219035 | — | — | 1 | 6.18 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | — | 1 | 5.70 |
| CHEMBL428650 | ENDOTHALL | — | 1 | 5.30 |
| CHEMBL5218547 | — | — | 1 | 4.21 |
| CHEMBL5218860 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48449 | CANTHARIDIN | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL1234720 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5219035 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL428650 | ENDOTHALL | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5218547 | — | IC50 | = | 62200.0 | nM | 4.21 |
| CHEMBL5218860 | — | IC50 | > | 200000.0 | nM | - |