Assay Detail
Binding
CHEMBL5215369
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine brain PP2A assessed as dephosphorylation of substrate using P32 labelled peptide DLDVPIPGRFDRRVSVAAE as substrate by radiometric analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Antitumor potential of the protein phosphatase inhibitor, cantharidin, and selected derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.34 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48449 | CANTHARIDIN | 4.0 | 1 | 7.40 |
| CHEMBL1234720 | — | — | 1 | 7.30 |
| CHEMBL5219035 | — | — | 1 | 6.92 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | — | 1 | 6.43 |
| CHEMBL428650 | ENDOTHALL | — | 1 | 6.01 |
| CHEMBL5218547 | — | — | 1 | 4.00 |
| CHEMBL5218860 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48449 | CANTHARIDIN | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1234720 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5219035 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL428650 | ENDOTHALL | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL5218547 | — | IC50 | = | 99900.0 | nM | 4.00 |
| CHEMBL5218860 | — | IC50 | > | 200000.0 | nM | - |