Assay Detail
Functional
CHEMBL5215376
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Anticancer activity against human KB 3-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB 3-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor potential of the protein phosphatase inhibitor, cantharidin, and selected derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.61 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48449 | CANTHARIDIN | 4.0 | 1 | 5.57 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | — | 1 | 4.16 |
| CHEMBL1234720 | — | — | 1 | 4.10 |
| CHEMBL5218860 | — | — | 1 | - |
| CHEMBL5218547 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48449 | CANTHARIDIN | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | IC50 | = | 69500.0 | nM | 4.16 |
| CHEMBL1234720 | — | IC50 | = | 79200.0 | nM | 4.10 |
| CHEMBL5218860 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL5218547 | — | IC50 | = | 112000.0 | nM | - |