Assay Detail
Functional
CHEMBL5215410
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Antiplasmodial activity against chloroquine-sensitive asexual blood stage Plasmodium falciparum 3D7 assessed as inhibition of parasite growth incubated for 1 hr by HRP2-ELISA
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
3-Hydroxy-propanamidines, a New Class of Orally Active Antimalarials Targeting Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.85 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4081080 | — | — | 1 | 8.70 |
| CHEMBL5218652 | — | — | 1 | 8.30 |
| CHEMBL5219819 | — | — | 1 | 8.30 |
| CHEMBL38827 | LUMEFANTRINE | 4.0 | 1 | 8.22 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.22 |
| CHEMBL5218647 | — | — | 1 | 8.15 |
| CHEMBL5220570 | — | — | 1 | 7.57 |
| CHEMBL5218542 | — | — | 1 | 7.30 |
| CHEMBL5218669 | — | — | 1 | 7.30 |
| CHEMBL5220102 | — | — | 1 | 7.16 |
| CHEMBL5218836 | — | — | 1 | 6.62 |
| CHEMBL5221044 | — | — | 1 | 6.55 |
| CHEMBL5218927 | — | — | 1 | 6.48 |
| CHEMBL5220409 | — | — | 1 | 6.48 |
| CHEMBL5218774 | — | — | 1 | 6.46 |
| CHEMBL5219351 | — | — | 1 | 6.32 |
| CHEMBL5219148 | — | — | 1 | 6.14 |
| CHEMBL5219672 | — | — | 1 | 6.01 |
| CHEMBL5219009 | — | — | 1 | 5.82 |
| CHEMBL5219192 | — | — | 1 | 5.68 |
| CHEMBL5221115 | — | — | 1 | 5.47 |
| CHEMBL5219233 | — | — | 1 | 5.47 |
| CHEMBL5219083 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4081080 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5218652 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5219819 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL38827 | LUMEFANTRINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5218647 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5220570 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5218542 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5218669 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5220102 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5218836 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5221044 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5218927 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5220409 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5218774 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5219351 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5219148 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL5219672 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL5219009 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5219192 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5221115 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5219233 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5219083 | — | IC50 | = | 15000.0 | nM | 4.82 |