Assay Detail
Functional
CHEMBL5215411
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against multidrug resistant asexual blood stage Plasmodium falciparum Dd2 assessed as inhibition of parasite growth incubated for 1 hr by HRP2-ELISA
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
3-Hydroxy-propanamidines, a New Class of Orally Active Antimalarials Targeting Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.41 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38827 | LUMEFANTRINE | 4.0 | 1 | 8.70 |
| CHEMBL5218652 | — | — | 1 | 8.05 |
| CHEMBL5219819 | — | — | 1 | 7.92 |
| CHEMBL5218647 | — | — | 1 | 7.85 |
| CHEMBL5220570 | — | — | 1 | 7.40 |
| CHEMBL5218669 | — | — | 1 | 7.30 |
| CHEMBL5218836 | — | — | 1 | 6.92 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.64 |
| CHEMBL5218774 | — | — | 1 | 6.64 |
| CHEMBL5221044 | — | — | 1 | 6.54 |
| CHEMBL5218927 | — | — | 1 | 6.46 |
| CHEMBL5218542 | — | — | 1 | 6.19 |
| CHEMBL5220102 | — | — | 1 | 6.16 |
| CHEMBL5219009 | — | — | 1 | 6.03 |
| CHEMBL5220409 | — | — | 1 | 5.96 |
| CHEMBL5219351 | — | — | 1 | 5.82 |
| CHEMBL5221115 | — | — | 1 | 5.62 |
| CHEMBL5219192 | — | — | 1 | 5.29 |
| CHEMBL5219233 | — | — | 1 | 5.25 |
| CHEMBL5219148 | — | — | 1 | 5.00 |
| CHEMBL5219672 | — | — | 1 | 4.70 |
| CHEMBL5219083 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38827 | LUMEFANTRINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5218652 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5219819 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5218647 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5220570 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5218669 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5218836 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5218774 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5221044 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5218927 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5218542 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5220102 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5219009 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL5220409 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5219351 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5221115 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5219192 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL5219233 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL5219148 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5219672 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5219083 | — | IC50 | = | 22800.0 | nM | 4.64 |