Assay Detail
Binding
CHEMBL5215683
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His tagged PHD2 (181 to 426 residues) (unknown origin) measured by MALDI-TOF MS analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.62 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3646118 | MOLIDUSTAT | 2.0 | 1 | 8.15 |
| CHEMBL3646221 | VADADUSTAT | 4.0 | 1 | 7.54 |
| CHEMBL3544988 | DAPRODUSTAT | 4.0 | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3646118 | MOLIDUSTAT | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3646221 | VADADUSTAT | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3544988 | DAPRODUSTAT | IC50 | = | 67.0 | nM | 7.17 |