Assay Detail
Binding
CHEMBL5215714
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Inhibition of human IDO1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.69 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4161733 | — | — | 1 | 8.77 |
| CHEMBL4778760 | LY-3381916 | 1.0 | 1 | 8.15 |
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 8.00 |
| CHEMBL5203175 | — | — | 1 | 7.54 |
| CHEMBL5177466 | — | — | 1 | 7.11 |
| CHEMBL5219380 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4161733 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4778760 | LY-3381916 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5203175 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5177466 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5219380 | — | IC50 | = | 260.0 | nM | 6.58 |