Assay Detail
Binding
CHEMBL5215716
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Binding affinity to human IDO1 assessed as inhibition constant
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.22 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3989951 | NAVOXIMOD | 2.0 | 1 | 7.72 |
| CHEMBL571209 | INDOXIMOD | 2.0 | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3989951 | NAVOXIMOD | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL571209 | INDOXIMOD | Ki | = | 19000.0 | nM | 4.72 |