Assay Detail
Binding
CHEMBL5215848
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat alpha9alpha10 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response incubated for 5 mins in presence of Ach stimulation by voltage-clamp based electrophysiological method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Nicotinic acetylcholine receptor alpha9/alpha10 (CHEMBL3038462) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Selective Penicillamine Substitution Enables Development of a Potent Analgesic Peptide that Acts through a Non-Opioid-Based Mechanism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.00 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5219936 | — | — | 1 | 9.41 |
| CHEMBL5220820 | — | — | 1 | 8.94 |
| CHEMBL5220229 | — | — | 1 | 8.83 |
| CHEMBL5220778 | — | — | 1 | 8.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5219936 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL5220820 | — | IC50 | = | 1.15 | nM | 8.94 |
| CHEMBL5220229 | — | IC50 | = | 1.47 | nM | 8.83 |
| CHEMBL5220778 | — | IC50 | = | 1.49 | nM | 8.83 |