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Assay Detail

CHEMBL5216079

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human ACE2 using fluorogenic peptide substrate VI measured every 36 sec for 10 mins by fluorescence reader analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Angiotensin-converting enzyme 2 (CHEMBL3736)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Enzyme inhibition as a potential therapeutic strategy to treat COVID-19 infection.
Paulsson-Habegger L, Snabaitis AK, Wren SP.
Bioorg Med Chem (2021) 48 : 116389 -116389
PubMed 34543844 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.24 4.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3219078 1 4.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3219078 IC50 = 57000.0 nM 4.24