Assay Detail
Binding
CHEMBL5216253
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Inhibition of IDO1 (unknown origin)
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual-target inhibitors of indoleamine 2, 3 dioxygenase 1 (Ido1): A promising direction in cancer immunotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.61 | 9.92 |
| Ki | 1 | 7.55 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4086143 | PF-06840003 | 1.0 | 1 | 9.92 |
| CHEMBL4787695 | — | — | 1 | 8.30 |
| CHEMBL4756155 | — | — | 1 | 7.89 |
| CHEMBL3989951 | NAVOXIMOD | 2.0 | 1 | 7.55 |
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 7.14 |
| CHEMBL4300931 | — | — | 1 | 7.00 |
| CHEMBL4763910 | — | — | 1 | 5.93 |
| CHEMBL4749277 | — | — | 1 | 5.50 |
| CHEMBL4790494 | — | — | 1 | 5.08 |
| CHEMBL5219208 | — | — | 1 | 4.85 |
| CHEMBL4749687 | — | — | 1 | 4.45 |
| CHEMBL5220249 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4086143 | PF-06840003 | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL4787695 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4756155 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3989951 | NAVOXIMOD | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4300931 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4763910 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL4749277 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL4790494 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL5219208 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4749687 | — | IC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL5220249 | — | IC50 | = | 227000.0 | nM | - |