Assay Detail
Binding
CHEMBL5216307
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HER2 (unknown origin) incubated for 1 hr in presence of ATP by Kinase-Glo Plus luminescence kinase assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor tyrosine-protein kinase erbB-2 (CHEMBL1824) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent contribution of medicinally active 2-aminothiophenes: A privileged scaffold for drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 10.04 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL941 | IMATINIB | 4.0 | 1 | 10.22 |
| CHEMBL5221067 | — | — | 1 | 9.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL941 | IMATINIB | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL5221067 | — | IC50 | = | 0.14 | nM | 9.85 |