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Assay Detail

CHEMBL5216513

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human IDO1
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Indoleamine 2,3-dioxygenase 1 (CHEMBL4685)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of the First Selective IDO2 Inhibitor As Novel Immunotherapeutic Avenues for Rheumatoid Arthritis.
He G, Wan S, Wu Y, Chu Z, Shen H, Zhang S, Chen L, Bao Z, Gu S, Huang J, Huang L, Gong G, Zou Y, Zhu Q, Xu Y.
J Med Chem (2022) 65 : 14348 -14365
PubMed 35952367 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 7.20 7.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5091825 1 7.55
CHEMBL5221037 1 7.43
CHEMBL5220224 1 7.33
CHEMBL5221035 1 7.28
CHEMBL5219888 1 6.39
CHEMBL5219050 1 -
CHEMBL5219670 1 -
CHEMBL5219166 1 -
CHEMBL5221052 1 -
CHEMBL5219627 1 -
CHEMBL5220174 1 -
CHEMBL5220058 1 -
CHEMBL5220112 1 -
CHEMBL5219521 1 -
CHEMBL5218706 1 -
CHEMBL5220905 1 -
CHEMBL5218638 1 -
CHEMBL5220365 1 -
CHEMBL5218514 1 -
CHEMBL5219143 1 -
CHEMBL5218855 1 -
CHEMBL5218715 1 -
CHEMBL5219677 1 -
CHEMBL5220617 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5091825 IC50 = 28.0 nM 7.55
CHEMBL5221037 IC50 = 37.0 nM 7.43
CHEMBL5220224 IC50 = 47.0 nM 7.33
CHEMBL5221035 IC50 = 52.0 nM 7.28
CHEMBL5219888 IC50 = 411.0 nM 6.39
CHEMBL5219050 IC50 - -
CHEMBL5219670 IC50 - -
CHEMBL5219166 IC50 - -
CHEMBL5221052 IC50 - -
CHEMBL5219627 IC50 - -
CHEMBL5220174 IC50 - -
CHEMBL5220058 IC50 - -
CHEMBL5220112 IC50 - -
CHEMBL5219521 IC50 - -
CHEMBL5218706 IC50 - -
CHEMBL5220905 IC50 - -
CHEMBL5218638 IC50 - -
CHEMBL5220365 IC50 - -
CHEMBL5218514 IC50 - -
CHEMBL5219143 IC50 - -
CHEMBL5218855 IC50 - -
CHEMBL5218715 IC50 - -
CHEMBL5219677 IC50 - -
CHEMBL5220617 IC50 - -