Assay Detail
Functional
CHEMBL5216554
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Cytotoxicity against human HepG2 cells assessed as cell growth inhibition
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent advances in combretastatin A-4 codrugs for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.27 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 8.40 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.89 |
| CHEMBL5218646 | — | — | 1 | 7.64 |
| CHEMBL5219317 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 12.85 | nM | 7.89 |
| CHEMBL5218646 | — | IC50 | = | 22.78 | nM | 7.64 |
| CHEMBL5219317 | — | IC50 | = | 7333.0 | nM | 5.13 |