Assay Detail
Binding
CHEMBL5216704
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Inhibition of [3H]-PDBu binding to PKCdelta C1B domain (unknown origin) by competitive binding assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A simplified analog of debromoaplysiatoxin lacking the B-ring of spiroketal moiety retains protein kinase C-binding and antiproliferative activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.56 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1258117 | — | — | 1 | 8.01 |
| CHEMBL5220744 | — | — | 1 | 7.77 |
| CHEMBL5219806 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1258117 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL5220744 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL5219806 | — | Ki | = | 130.0 | nM | 6.89 |