Assay Detail
Binding
CHEMBL5216902
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Inhibition of recombinant human MAO-B
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, in-vitro, in-vivo and ex-vivo pharmacology of thiazolidine-2,4-dione derivatives as selective and reversible monoamine oxidase-B inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.62 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363555 | — | — | 1 | 7.09 |
| CHEMBL1222280 | — | — | 1 | 6.71 |
| CHEMBL7002 | CIGLITAZONE | 2.0 | 1 | 6.65 |
| CHEMBL595 | PIOGLITAZONE | 4.0 | 1 | 6.53 |
| CHEMBL5219355 | — | — | 1 | 6.23 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 6.08 |
| CHEMBL5220140 | — | — | 1 | 6.05 |
| CHEMBL5219947 | — | — | 1 | 6.01 |
| CHEMBL5219976 | — | — | 1 | 5.99 |
| CHEMBL5219890 | — | — | 1 | 5.79 |
| CHEMBL5219078 | — | — | 1 | 5.74 |
| CHEMBL5220565 | — | — | 1 | 5.72 |
| CHEMBL408 | TROGLITAZONE | 4.0 | 1 | 5.68 |
| CHEMBL5219886 | — | — | 1 | 5.53 |
| CHEMBL1466353 | — | — | 1 | 5.45 |
| CHEMBL5220624 | — | — | 1 | 5.25 |
| CHEMBL5220045 | — | — | 1 | 5.24 |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | 5.09 |
| CHEMBL5219373 | — | — | 1 | 5.03 |
| CHEMBL5219309 | — | — | 1 | 4.96 |
| CHEMBL5220446 | — | — | 1 | 4.89 |
| CHEMBL5220267 | — | — | 1 | 4.81 |
| CHEMBL5219831 | — | — | 1 | 4.74 |
| CHEMBL5218996 | — | — | 1 | 4.66 |
| CHEMBL5219449 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363555 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL1222280 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL7002 | CIGLITAZONE | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL595 | PIOGLITAZONE | IC50 | = | 298.0 | nM | 6.53 |
| CHEMBL5219355 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL121 | ROSIGLITAZONE | IC50 | = | 832.0 | nM | 6.08 |
| CHEMBL5220140 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5219947 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL5219976 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL5219890 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL5219078 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL5220565 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL408 | TROGLITAZONE | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL5219886 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL1466353 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL5220624 | — | IC50 | = | 5690.0 | nM | 5.25 |
| CHEMBL5220045 | — | IC50 | = | 5730.0 | nM | 5.24 |
| CHEMBL396778 | SAFINAMIDE | IC50 | = | 8160.0 | nM | 5.09 |
| CHEMBL5219373 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL5219309 | — | IC50 | = | 10860.0 | nM | 4.96 |
| CHEMBL5220446 | — | IC50 | = | 12730.0 | nM | 4.89 |
| CHEMBL5220267 | — | IC50 | = | 15340.0 | nM | 4.81 |
| CHEMBL5219831 | — | IC50 | = | 18070.0 | nM | 4.74 |
| CHEMBL5218996 | — | IC50 | = | 21670.0 | nM | 4.66 |
| CHEMBL5219449 | — | IC50 | = | 22090.0 | nM | 4.66 |