Assay Detail
Functional
CHEMBL5216917
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Antiproliferative activity against human AGS cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | AGS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Boronic Acid: A Novel Pharmacophore Targeting Src Homology 2 (SH2) Domain of STAT3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.62 | 5.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5220221 | — | — | 1 | 5.81 |
| CHEMBL5220210 | — | — | 1 | 5.76 |
| CHEMBL5218494 | — | — | 1 | 5.70 |
| CHEMBL5219582 | — | — | 1 | 5.59 |
| CHEMBL5219079 | — | — | 1 | 5.56 |
| CHEMBL3108909 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5220221 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL5220210 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL5218494 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL5219582 | — | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL5219079 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL3108909 | — | IC50 | = | 5420.0 | nM | 5.27 |